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    Data summary

    • Publications : 991
    • Phenotypes : 178
    • Genes : 207
    • Mutations : 4583
    • SNVs : 3411
    • InDels : 1172
    • Last Update : 05/11/2017

    Detailed information for MERTK






    Basic information
    Official symbolMERTK
    Official full namec-mer proto-oncogene tyrosine kinase
    Location2q14.1
    Gene typeprotein-coding
    SynonymsMER|RP38|c-mer
    Quick linksEntrez ID:10461; HGNC:7027; MIM:604705; Ensembl:ENSG00000153208; HPRD:05269; Vega:OTTHUMG00000131278
    GO related
    GO term accessionGO term nameNumber of reference genesNumber of genesExpected numberRatio of enrichmentP-valueAdjusted P-Value
    GO:0060041retina development in camera-type eye105311.3123.731.13e-341.90e-32
    GO:0007423sensory organ development436485.428.853.27e-323.84e-30
    GO:0001654eye development276393.4311.363.01e-302.94e-28
    GO:0044707single-multicellular organism process561214369.812.059.21e-297.72e-27
    GO:0032501multicellular organismal process564414370.212.041.83e-281.43e-26
    GO:0043010camera-type eye development237332.9511.192.13e-251.25e-23
    GO:0044699single-organism process768215295.571.599.26e-193.88e-17
    GO:0009653anatomical structure morphogenesis20557025.562.741.99e-167.08e-15
    GO:0048856anatomical structure development403010250.132.034.19e-161.33e-14
    GO:0000902cell morphogenesis9454211.763.572.49e-137.69e-12
    GO:0032502developmental process457210456.881.833.53e-131.04e-11
    GO:0005488binding11955150132.971.130.00050.0090
    GO:0005515protein binding733710281.611.250.00110.0149
    GO:0043168anion binding24024026.721.500.00480.0336
    GO:0005929cilium239552.6121.102.59e-585.08e-56
    GO:0031513nonmotile primary cilium80320.8736.671.40e-421.37e-40
    GO:0072372primary cilium96331.0531.522.93e-411.91e-39
    GO:0042995cell projection12306713.424.995.15e-302.02e-28
    GO:0001750photoreceptor outer segment37190.4047.083.03e-289.90e-27
    GO:0044459plasma membrane part19184120.921.961.68e-059.98e-05
    Pathway related
    TermSurceNumber of reference genesNumber of genesExpected numberRatio of enrichmentP-valueAdjusted P-value
    PPI related
    IDNumber of reference genesNumber of genesExpected numberRatio of enrichmentP-valueAdjusted P-value
    OMIM related
    chromosomebeginenddisorder MIM numberdisorderphene mapping keygene/locus MIM numbercytogenetic loaction
    chr2112655190112787945613862Retinitis pigmentosa 3836047052q13
    MGI related
    chromosomebeginendgene IDgene symbol of mouseMGIMPphenotype description
    chr211265519011278794510461MertkMGI:96965MP:0001186pigmentation phenotype
    chr211265519011278794510461MertkMGI:96965MP:0003631nervous system phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005370liver/biliary system phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005376homeostasis/metabolism phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005379endocrine/exocrine gland phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005381digestive/alimentary phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005384cellular phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005385cardiovascular system phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005387immune system phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005389reproductive system phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005390skeleton phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005391vision/eye phenotype
    chr211265519011278794510461MertkMGI:96965MP:0005397hematopoietic system phenotype
    chr211265519011278794510461MertkMGI:96965MP:0010768mortality/aging
    chr211265519011278794510461MertkMGI:96965MP:0010771integument phenotype
    Mutation spectrum

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    Gene-disease network

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